Effect of Ca antagonist and calmodulin inhibitor on Ca-dependent K channels in isolated smooth muscle cells
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چکیده
منابع مشابه
cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells.
Guanosine-3',5'-cyclic monophosphate (cGMP)-dependent protein kinase (cGMP-PK) plays a central role in the mediation of the vasodilator response to nitric oxide (NO) and other nitrovasodilators. It is unclear whether cGMP-PK affects calcium-activated potassium channels (KCa channels) or any other type of ion channel in smooth muscle. We provide here the first direct evidence that cGMP-PK can ac...
متن کاملKinetic differences between Ca(2+)-dependent K+ channels in smooth muscle cells isolated from normal and atherosclerotic human aorta.
The properties of large conductance Ca(2+)-dependent K+ channels in smooth muscle cells (SMC) isolated from normal and atherosclerotic human aorta were studied using the patch-clamp technique. It was shown that SMC from normal human aorta possess a homogeneous population of normal Ca(2+)-dependent K+ channels. In atherosclerotic aorta two kinetically different types of these channels could be d...
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Han, Jin, Nari Kim, Hyun Joo, and Euiyong Kim. Ketamine blocks Ca2 -activated K channels in rabbit cerebral arterial smooth muscle cells. Am J Physiol Heart Circ Physiol 285: H1347–H1355, 2003; 10.1152/ajpheart.00194. 2003.—Although ketamine and Ca2 -activated K (KCa) channels have been implicated in the contractile activity regulation of cerebral arteries, no studies have addressed the specifi...
متن کاملPeroxynitrite reversibly inhibits Ca(2+)-activated K(+) channels in rat cerebral artery smooth muscle cells.
Peroxynitrite (ONOO(-)) is a contractile agonist of rat middle cerebral arteries. To determine the mechanism responsible for this component of ONOO(-) bioactivity, the present study examined the effect of ONOO(-) on ionic current and channel activity in rat cerebral arteries. Whole cell recordings of voltage-clamped cells were made under conditions designed to optimize K(+) current. The effects...
متن کاملConservation of Ca/Calmodulin Regulation across Na and Ca Channels
Manu Ben-Johny,1 Philemon S. Yang,1 Jacqueline Niu,1 Wanjun Yang,1 Rosy Joshi-Mukherjee,1 and David T. Yue1,* 1Calcium Signals Laboratory, Departments of Biomedical Engineering and Neuroscience and Center for Cell Dynamics, The Johns Hopkins University School of Medicine, Ross Building, Room 713, 720 Rutland Avenue, Baltimore, MD 21205, USA *Correspondence: [email protected] http://dx.doi.org/10.10...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1986
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)59471-9